相关实验视频

Updated: Jun 15, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

在住院的早产婴儿中,肠道微生物组发育和干扰的临床后果

Robert Thänert¹, Drew J Schwartz², Eric C Keen³

¹The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Cell host & microbe

|August 28, 2024

概括

产前婴儿肠道微生物组的发展在很大程度上受到医疗治疗的影响,而不仅仅是母亲的因素. 这项研究揭示了关键的细菌群体,并将低多样性的微生物组与早产婴儿的死性肠球炎联系起来.

科学领域:

微生物组研究微生物组研究
新生儿重症监护室 (NICU) 研究研究
儿科健康儿科健康

背景情况:

过早出生婴儿的异常肠道微生物殖民与早期生活障碍和长期健康问题有关.
了解住院早产新生儿肠道微生物组组合的动态对于改善健康结果至关重要.

研究的目的:

在早产婴儿生命的前三个月内描述肠道微生物组的动态.
调查医疗干预,母体和基线变量对婴儿肠道微生物组成的影响.
为了识别与死性肠球炎的发展相关的微生物特征.

主要方法:

在3个NICU的236名早产婴儿的便样本上进行了枪支元基因组学和元转录学.
分析包括菌株追踪,分类学和功能分析,以及与综合临床元数据的整合.
纵向数据收集涵盖了生命的前三个月.

主要成果:

肠杆菌,肠球菌和葡萄球菌被确定为早产婴儿肠道的主导殖民者.
特定的Clostridioides difficile和Staphylococcus epidermidis的血统在中心内和中心之间表现出持久性.
抗生素和非抗生素药物对肠道微生物组合的影响比孕产妇或基线因素更大.
在40天后患有死角性肠球炎的新生儿表现出持久的低多样性肠道微生物群.

结论:

医疗干预显著地影响了早产婴儿的肠道微生物组组,比母亲或基线变量更重要.
持续的低多样性肠道微生物组与这种脆弱人群中死性肠球炎的发展有关.
这项研究提供了肠道微生物组动态的全面描述,以响应住院早产新生儿的医疗干预.

关键词:

抗生素抗生素是一种抗生素.显露体显露体显露体我们的肠道微生物组.转基因组学是指转基因组学.转换组学转换组学转换组学微生物组的变化发生了变化.死性肠球炎 (necrotizing enterocolitis) 是一种致死性肠球炎.新生儿重症监护室新生儿重症监护室过早出生的婴儿早产.

更多相关视频

Probiotic Studies in Neonatal Mice Using Gavage

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

相关概念视频

Anatomy of the Intestines

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...