发病发炎性关节炎的风险在开始生物治疗的牛皮患者:基于人口的分析分析
Bruce Strober1, Ahmed M Soliman2, Chao Li2
1Department of Dermatology, Yale University, New Haven, Connecticut; Central Connecticut Dermatology, Cromwell, Connecticut.
Journal of the American Academy of Dermatology
|August 28, 2024
概括
与IL-17和瘤死因因子 (TNF) 抑制剂相比,接受过IL-23 (IL-23) 抑制剂的牛皮 (PsO) 患者患炎症性关节炎的风险较低.
科学领域:
- 皮肤病学和风湿病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 牛皮 (PsO) 生物药物与新发炎性关节炎之间的联系尚未得到充分证实.
- 了解这种关系对于优化PsO治疗策略至关重要.
研究的目的:
- 调查不同类别的生物治疗PsO和随后的炎症性关节炎的发展之间的关联.
- 为了比较PsO患者在各种生物亚类中的炎症性关节炎的风险.
主要方法:
- 从2007年1月到2023年3月对PsO患者的回顾性分析.
- 根据最初的生物学分层:IL-23,IL-12/23,IL-17或TNF抑制剂.
- 用于评估风险的多变量Cox比例危险模型,以IL-23抑制剂作为参考.
主要成果:
- 炎症性关节炎的发病率 (事件/100人/年) 为4.99 (IL-23),7.29 (IL-17),6.06 (IL-12/23) 和9.39 (TNF).
- 调整后的危险比率显示IL-17 (1.44) 和TNF (1.90) 抑制剂与IL-23抑制剂的风险显著更高.
- IL-23抑制剂显示,患炎症性关节炎的风险较低.
结论:
- 干白素-23抑制剂与PSO患者患炎症性关节炎,包括牛皮性关节炎的风险降低有关.
- 这一发现表明IL-23抑制剂在缓解关节炎发展方面具有潜在的益处.
- 研究的局限性包括依赖医疗编码和潜在的原发病偏见.
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