针对寡进型固体瘤的立体性废除性放射治疗:系统性审查和元分析
Vivian S Tan1, Jerusha Padayachee2, George B Rodrigues1
1Department of Radiation Oncology, Western University, London, Canada.
概括
立体性除性放射治疗 (SABR) 对寡进性转移的疗效不同,前列腺癌和肺癌的无进展生存率更高. 对于其他类型的癌症还需要更多的研究.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
背景情况:
- 寡进性转移代表了癌症管理中的临床挑战.
- 立体性除性放射疗法 (SABR) 是有限转移性疾病的新兴治疗方式.
研究的目的:
- 系统地审查和元分析SABR在患有寡进性转移的患者中的有效性.
- 结合临床结果,包括无进展生存率 (PFS) 和整体生存率 (OS).
主要方法:
- 从2010年1月到2023年1月,在五个数据库中进行了全面的文献搜索.
- 包括的研究集中在患有寡进性疾病的患者身上,这些患者在所有病变中接受了SABR治疗.
- 聚合分析使用二进制随机效应模型来评估结果.
主要成果:
- 25项研究符合资格标准,2017年后的出版物激增,主要是在2021-2022年.
- 综合1年的PFS为44% (95% CI: 34-53%),主要瘤部位的显著变化.
- 具体的一年PFS率包括:前列腺 (53%), (49%),肺 (62%),乳腺 (13%) 和混合 (30%).
结论:
- 有越来越多的关于SABR对寡进瘤的文献,主要是前列腺癌和癌的回顾性研究.
- 有限证据表明SABR在其他癌症类型中的有效性.
- 建议制定标准指南,以便在未来的研究中提供一致的报告和可比性.
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