设计V类型的深度浸泡溶剂,使用抗疟疾药物成分
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Updated: Jun 15, 2025
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Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
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Gabriel Teixeira1, Paula Brandão1, Ana I M C Lobo Ferreira2
1CICECO, Aveiro Institute of Materials, Complexo de Laboratórios Tecnológicos, University of Aveiro, Campus Universitário de Santiago, Aveiro, Portugal.
概括
研究人员探索了使用活性药物成分和辅助剂的深度环氧溶剂,以提高药物的溶解性. 他们发现了新的共晶体,并证实了九个系统的负偏离理想性,进步了药物配方科学.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 物理化学 物理化学
背景情况:
- 活性制药成分经常面临溶解性,生物可用性和透性方面的挑战.
- 深度性溶剂 (DESs) 提供了一种有希望的方法来克服这些局限性.
- 开发新型DES需要对药物和辅助成分进行仔细的选择.
研究的目的:
- 通过使用特定的活性药物成分和潜在的辅助物质,研究深层浸泡性溶剂的形成.
- 通过DES配方解决与药物溶解性,生物可用性和透性相关的挑战.
- 选和识别有前途的辅助剂用于药物输送应用.
主要方法:
- 使用COSMO-RS热力学模型对辅助剂进行初步选.
- 使用视觉化和差分扫描热量计,对九个固体液体平衡 (SLE) 阶段图进行实验测量.
- 使用粉末和单晶X射线衍射,对新的共晶体进行表征.
- 使用COSMO-RS (TZVP和TZVPD-FINE参数化) 进行SLE图的热力学建模.
主要成果:
- 三种辅助物质 (甲基醇,基酸盐,丁酸酸盐) 被认为是有前途的.
- 所有九个研究的系统都表现出了与热力学理想性相对的负偏差.
- 发现了四种新的共晶体,并进行了结构验证.
- 在COSMO-RS模型中,TZVP和TZVPD-FINE参数之间显示了可变的准确性.
结论:
- 通过精选的活性药物成分和辅助剂,可以有效地形成深度浸泡溶剂.
- 该研究确定了新的共晶体,并提供了对这些系统的热力学行为的洞察.
- 进一步的研究可以利用这些发现来改善药物配方和输送.
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