含有甘氨酸酸的发化品会诱导结晶性脏病
Thomas Robert1, Ellie Tang2, Jennifer Kervadec2
1Centre of Nephrology and Renal Transplantation, Hôpital de la Conception, CHU de Marseille, Marseille, France; Aix Marseille Université, INSERM, INRAE, C2VN, Marseille, France.
Kidney international
|August 28, 2024
概括
巴西式"发型理疗法"含有氧酸可导致急性损伤. 局部应用导致小鼠中酸盐分泌量增加和酸盐脏病,突出了这些化品的潜在风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 皮肤病学 皮肤病学
- 毒理学 毒理学 毒理学
背景情况:
- 急性损伤 (AKI) 是一种严重的疾病,可能是各种因素造成的.
- 之前的一份病例报告将连续的AKI发作与特定的发治疗联系起来.
- 涉及的化品含有甘酸,促使对其毒性潜力进行调查.
研究的目的:
- 调查发型产品中氧酸可能导致损伤的潜在机制.
- 在小鼠模型中,评估局部应用氧酸和商用发器对功能和氧酸盐代谢的影响.
主要方法:
- 四组小鼠接受了局部应用:发型理产品,10%的甘酸奶油,10%的甘酸奶油或对照奶油.
- 测量尿液中氧酸盐的分泌量.
- 检查脏组织以检查脏病的迹象,特别是氧化酸晶体沉积.
主要成果:
- 在小鼠身上,局部应用的发型理产品和糖酸奶油显著增加了尿液中氧酸盐的分泌.
- 酸和直产品都诱导了酸盐脏病,表明脏受损.
- 葡萄糖酸的应用显示尿液中酸盐分泌量略有增加,没有观察到显著的脏病.
结论:
- 从化品直发产品中通过皮肤吸收的氧酸被代谢成氧酸盐.
- 这种过度的氧酸盐生产促进了氧酸盐在脏中的结晶,导致急性损伤.
- 由于其潜在的毒性作用,含有酸的化品应谨慎使用.
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