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同轴电纳米纤维通过工程化益生菌生物膜加速受感染的伤口愈合

Bohan Huang¹, Feng Xiao², Zesheng Chen³

¹Department of Urology, Institute of Urology, Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Ministry of Education Key Laboratory of the Green Preparation and Application for Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan 430062, China.

International journal of biological macromolecules

|August 28, 2024

概括

使用纳米纤维膜的新型益生菌生物膜策略有效治疗受感染的伤口. 这种方法增强了组织再生,与商业带相比显示出更优异的结果,为临床使用提供了潜力.

科学领域:

生物材料科学生物材料科学
伤口治愈研究研究伤口治愈研究
传染病治疗方法传染病治疗方法

背景情况:

细菌感染通过创建有害的伤口微环境 (WME) 来显著延迟伤口愈合.
现有的治疗方法往往难以有效地管理受感染的伤口,并促进组织再生.

研究的目的:

开发和评估一种基于益生菌生物膜的新型抗菌策略,用于感染伤口的治疗.
调查益生菌生物膜装载纳米纤维膜在促进伤口愈合和组织再生方面的有效性.

主要方法:

同轴电被用于制备聚烯酸 (PCL) /丝纤维素 (SF) 纳米纤维薄膜 (PSN-n).
最佳的PSN-1.5膜与L. paracasei共同培养,形成一个益生菌生物膜,产生PSNL-1.5.5.
物理化学性质,抗菌活性,生物相容性和亲再生能力 (包括M2巨细胞免疫调节) 被描述.
在感染 Staphylococcus aureus 的皮肤缺陷模型上进行了伤口愈合测试.

主要成果:

PSNL-1.5表现出广泛的抗菌活性和良好的生物相容性.
通过M2巨细胞免疫调节,PSNL-1.5表现出增强的亲再生能力.
在体内研究表明,PSNL-1.5在治愈受感染的伤口方面明显优于商业纳米银.

结论:

与纳米纤维膜集成的益生菌生物膜代表了一个有前途的抗菌和亲再生治疗策略.
开发的PSNL-1.5敷料显示出在治疗感染的伤口方面临床应用的巨大潜力.
这项研究强调了使用益生菌生物膜用于高级伤口护理的新性和有效性.

关键词:

细菌生物膜是一种细菌生物膜.同轴电旋转的电旋转方式.在M2巨细胞中.益生菌是一种益生菌.伤口愈合伤口愈合

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