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Updated: Jul 20, 2026

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays
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对11种数据较差的双A替代品的高通量转录组学毒性评估

Marc A Beal1, Melanie C Coughlan1, Andrée Nunnikhoven1

  • 1Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Canada.

Environmental pollution (Barking, Essex : 1987)
|August 28, 2024
PubMed
概括

这项研究使用了体外高通量转录组学来评估11种双A (BPA) 替代品. 九种化学物质改变了基因表达,其中一种显示出比BPA更高的强度,有助于识别更安全的替代品.

关键词:
双 A 是一种双.内分泌干扰 干扰内分泌系统在MCF-7中使用.新方法方法论新方法方法论可悲的替代品可惜的替代品.毒素基因组学 毒素基因组学

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...