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Updated: Jun 15, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
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用AlphaFold模型弥合蛋白质的序列和结构分类之间的差距

Jimin Pei1, Antonina Andreeva2, Sara Chuguransky2

  • 1Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Journal of molecular biology
|August 28, 2024
PubMed
概括

本研究使用AlphaFold预测和DPAM工具对蛋白质域进行分类,将基于序列的Pfam家族与基于结构的ECOD分类联系起来. 它揭示了新的域家族和进化关系,增强了我们对蛋白质宇宙的理解.

关键词:
在AlphaFold结构建模中.这是一个DPAMDPAM.在 ECOD 中,我们可以使用 ECOD.普法姆 (Pfamfam) 是一个家庭.蛋白质的分类 蛋白质的分类

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