基于16S rRNA基因测序的结直肠腺瘤-癌瘤序列中的肠道微生物群变化:系统性审查和元分析
Yi-Jun Wu1, Jing-Fang Xiong2, Cheng-Nan Zhan3
1The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Microbial pathogenesis
|August 28, 2024
概括
肠道微生物组的改变与结直肠癌 (CRC) 的进展有关. 这一元分析揭示了从腺瘤到癌瘤的特定细菌变化,突出了潜在的诊断标记.
科学领域:
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 大肠直肠癌 (CRC) 通常通过腺瘤-癌瘤序列发展.
- 肠道菌群失生症与CRC的发病有关,但具体的微生物关联仍然不清楚.
- 这项研究调查了腺瘤 (AD) 和CRC患者的肠道微生物特征.
研究的目的:
- 总结和分析患有结直肠腺瘤 (AD) 和结直肠癌 (CRC) 的患者肠道菌群的特征.
- 确定与从AD向CRC的进展相关的特定微生物种群.
主要方法:
- 一项对病例控制研究的元分析,比较了AD,CRC和健康对照 (HC) 的肠道微生物群.
- 在PubMed,Embase,Cochrane图书馆和科学网上搜索到2024年1月.
- 使用加权平均差异 (WMD) 分析了相对丰度,并使用纽卡斯尔-太华尺度 (NOS) 评估了研究质量.
主要成果:
- 与HC患者相比,AD患者的微生物多样性 (Chao 1和Shannon指数) 减少.
- 与AD患者相比,CRC患者的Chao 1和Shannon指数增加.
- 观察到特定的细菌变化:肠杆菌和蛋白质细菌的增加,在控制-AD-CRC进展过程中减少了蓝菌,菌和双菌.
结论:
- 失生症,标志着SCFA产生,抗炎,促炎和细胞毒性细菌的水平发生变化,是AD-CRC序列的特征.
- 这些微生物转移可能代表着结直肠腺瘤/结直肠癌的特定特征.
- 需要进一步的研究,以了解AD-CRC进展中的肠道失生症的机制,并探索临床应用的微生物群标志物.
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