改变基于加多的对比剂以预防复发的急性不良药反应:使用倾向性得分匹配的6年队列研究.
Min Woo Han1, Chong Hyun Suh2, Pyeong Hwa Kim2
1University of Ulsan College of Medicine, Seoul, Republic of Korea.
Korean journal of radiology
|August 28, 2024
概括
切换基于加多的对比剂 (GBCA) 显著降低了急性药物不良反应 (ADR) 的复发率. 这一发现为改善MRI过程中的患者安全提供了潜在的策略.
科学领域:
- 放射学和成像学 放射学和成像学
- 药物监督 药物监督 药物监督
- 患者安全 患者安全
背景情况:
- 基于加多的对比剂 (GBCA) 在MRI中被广泛使用.
- 在GBCA给药后,急性不良药反应 (ADR) 可能会发生.
- 尽量减少ADR复发的策略对于患者护理至关重要.
研究的目的:
- 评估GBCA切换对GBCA相关急性ADR复发的预防作用.
- 确定影响GBCA相关急性ADR复发的因素.
主要方法:
- 追溯性,观察性,单中心研究 (2016年1月 - 2023年7月).
- 对238,743个GBCA增强型MRI检查的分析.
- 使用多变量逻辑回归和倾向得分匹配,比较了GBCA切换患者和未切换患者之间的ADR复发率.
主要成果:
- 在GBCA增强的MRI检查中,急性ADR发生在0.44%.
- 在373名先前有急性副作用的患者中,31.9%的人出现了复发.
- 在GBCA变化组 (OR:0.35;P=0.03) 和过敏类过敏反应 (aOR:0.20;P<0.01) 中,ADR复发明显较低.
结论:
- 改变GBCA与减少GBCA相关的急性ADR复发风险有关.
- 这一策略可能会提高GBCA增强型MRI患者的安全性.
- 进一步的研究可以探索特定的GBCA类型和前期治疗方案.
更多相关视频
06:08Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
Published on: February 10, 2023
1.3K
11:27Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
9.9K
相关概念视频
Pharmacovigilance
789
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
789
Imaging Studies I: CT and MRI
207
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
207
Radiological Investigation I: X-ray and CT
218
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
218
Desensitization and Tachyphylaxis
1.6K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
1.6K
