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根据糖尿病进展,脂质水平与心力衰竭风险之间的不同关联
Seung-Hwan Lee1,2, Kyu Na Lee3, Jong-Chan Youn4
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Diabetes & metabolism journal
|August 28, 2024
概括
脂质水平显示了2型糖尿病中心力衰竭 (HF) 风险的变化. 早期糖尿病将较低的LDL-C与降低的HF风险联系在一起,而长期存在的糖尿病显示较高的HF风险与较高的LDL-C.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 循环脂水平与心力衰竭 (HF) 风险之间的关联受到争论.
- 2型糖尿病 (T2DM) 复杂化了这种关系,持续时间和治疗可能会改变风险.
研究的目的:
- 调查T2DM患者的脂质样本和发生性HF之间的关联.
- 为了确定糖尿病持续时间或抗糖尿病药物治疗方案是否会改变这种关联.
主要方法:
- 来自韩国国家健康信息数据库 (2015-2016) 的大量队列 (n=2,439,978).
- 根据糖尿病持续时间 (新发病,<5,5-10,≥10年) 和服用抗糖尿病药物的数量进行分层的受试者.
- 在住院期间通过ICD-10代码I50识别的事件HF;使用Cox比例危险模型分析风险.
主要成果:
- 在新发糖尿病中观察到LDL-C和HF风险之间的反向关联 (LDL-C较高的风险较低).
- 在长期糖尿病中观察到J形关联,在LDL-C≥160 mg/dL时,HF风险较高.
- 对于总胆固醇,非HDL-C和不同抗糖尿病药物组出现了类似的模式.
结论:
- 脂质水平与HF风险的关联因糖尿病进展而异.
- 疾病持续时间是影响T2DM患者脂质-HF关系的关键因素.
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