与代谢功能障碍相关的肥胖性肝病以及全因和因特定死亡率
Rosa Oh1, Seohyun Kim2, So Hyun Cho1
1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Diabetes & metabolism journal
|August 28, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 和相关疾病显著增加了全因和因特定死亡的风险. 早期发现和管理MASLD对于降低死亡风险至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
- 公共卫生 公共卫生
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 与代谢风险有关,这促使提出了一个新术语:与代谢功能障碍相关的脂肪性肝病 (MASLD).
- 了解与MASLD和相关肝病相关的死亡风险对于公共卫生至关重要.
- 脂肪性肝病 (SLD) 包含不同程度的代谢功能障碍和酒精消费的情况.
研究的目的:
- 调查MASLD与全因死亡率之间的关联.
- 探索MASLD和特定原因死亡率之间的关系,包括肝脏,癌症,肝细胞癌 (HCC) 和心血管 (CV) 原因.
- 为了比较不同类型的脂肪性肝病的死亡风险,包括MASLD,代谢性酒精相关肝病 (MetALD) 和代谢功能障碍 (MD) 的酒精性肝病 (ALD).
主要方法:
- 一个回顾性的全国性队列研究,利用来自韩国国家健康保险服务的数据.
- 包括1,298,993名年龄在40-79岁之间的个人,平均随访时间为9.04年.
- 根据酒精消耗和代谢功能障碍,SLD的分类为MASLD,MetALD和ALD与MD,SLD以脂肪肝指数≥30来定义.
主要成果:
- MASLD (aHR,1.28),MetALD (aHR,1.38),和ALD与MD (aHR,1.80) 都与与所有原因死亡率相比显著更高的风险有关.
- 没有SLD没有SLD
- 一个小组,一个小组.
- 所有带有MD组的MASLD,MetALD和ALD都表现出肝脏,癌症和HCC相关死亡率的风险增加.
- 虽然死亡风险通常从MASLD增加到MetALD,然后再增加到MD的ALD,但MetALD组的CV相关死亡风险低于MASLD,尽管MD的ALD仍然比MASLD具有更高的CV风险.
结论:
- 脂肪性肝病 (SLD),包括MASLD,MetALD和ALD与MD,与所有原因死亡率的增加显著相关.
- MASLD和相关疾病增加了肝脏,癌症,HCC和心血管相关死亡的风险.
- 这些发现强调了代谢功能障碍和酒精对肝脏健康和整体死亡率的关键影响.
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