通过补充确定区域移植技术生成具有不同物理化学和生物特性的子单链变量片段

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Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood
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Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood

Published on: February 6, 2018

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Ngoc Minh Nguyen1, Kiichi Nakao1, Ryo Kobayashi1

  • 1Faculty of Molecular Chemistry and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.

Journal of bioscience and bioengineering
|August 28, 2024
PubMed
概括

这项研究引入了一种新的补充确定区域 (CDR) 接种方法,用于子单链可变片段 (scFvs). 这种精细的技术成功地保持了抗原结合亲和力,并允许在工程抗体中具有多种物理化学性质.

关键词:
确定互补性的地区.补充-确定区域-接种.框架区域是指框架区域的区域.物理化学特性 物理化学特性蛋白质L-结合的蛋白质子单链变量碎片scFv 溶解度 溶解度 在

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