品牌和通用注射膏的流动性和粘度的差异
Atsushi Ishimura1, Chiaki Ogawa2, Megumi Yatabe3
1Division of Practical Pharmacy, Nihon Pharmaceutical University, Saitama, Japan.
Drug discoveries & therapeutics
|August 28, 2024
概括
通用和品牌注射膏可能因配方变化而在物理性能上有所不同. 这些粘度和传播能力的差异可能会影响患者的坚持和治疗结果.
科学领域:
- 制药科学 制药科学
- 类风病学 类风病学 类风病学
- 药物输送系统 药物输送系统
背景情况:
- 仿制药旨在实现与品牌药物的治疗等价性.
- 配方的差异,特别是局部药物,可能会影响可用性和患者的坚持.
- 可注射药膏具有独特的配方挑战,影响应用和有效性.
研究的目的:
- 为了比较品牌 (Posterisan® Forte) 和通用 (Hemoporison®) 注射膏的风湿性质.
- 评估配方变化如何影响粘度,扩散性和粘弹性等物理特征.
- 了解这些差异对临床结果和患者护理的潜在影响.
主要方法:
- 品牌和通用注射药膏的比较性风湿学分析.
- 在不同条件下评估粘度,延展性和粘弹性特性.
- 在不同温度下评估可扩散性和流动特性.
主要成果:
- 在各种温度范围内,Posterisan® Forte表现出卓越的扩散性和稳定的流量特性.
- 血素 (hemoporison®) 呈现出显著的厚度转移性行为和增加的硬度.
- 尽管相同的活性成分,但两种药膏之间观察到不同的物理性质.
结论:
- 通用和品牌注射乳膏之间的配方变化可能导致rheological属性的显著差异.
- 这些物理性质的差异可能会影响药膏的应用,患者的体验,以及潜在的治疗疗效.
- 对配方特异性的进一步调查对于确保可比的治疗性能和患者安全至关重要.
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