使用区域海平面脑血流预测急性山病
Hao Zhang1, Jie Feng2, Shi Yu Zhang3
1Chinese PLA Medical School, Beijing 100853, China;Department of Radiology, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Biomedical and environmental sciences : BES
|August 28, 2024
概括
海平面较高的大脑血流 (CBF),特别是在后部循环中,可能预测男性的急性山病 (AMS). 非侵入性3D-pCASL成像显示了AMS风险评估的潜力.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 高度医学 高度医学
背景情况:
- 急性山病 (AMS) 是高海拔地区常见的疾病.
- 预测AMS易感性仍然是一个挑战.
- 大脑血流 (CBF) 的调节对适应至关重要.
研究的目的:
- 调查海平面CBF对AMS的预测作用.
- 使用三维伪连续动脉旋转标记 (3D-pCASL) 进行非侵入性CBF测量.
- 为了比较AMS和非AMS组之间的CBF参数.
主要方法:
- 48名健康志愿者在海平面上进行3D-pCASLMRI,然后在3650米的高度上升.
- 分析了特定动脉区域 (ACA,MCA,PCA,PICA) 的CBF和侧面性指数 (LI).
- 统计分析和ROC曲线评估了AMS的预测性能.
主要成果:
- 平均皮层CBF在女性比男性更高.
- 在男性中,在海平面上ACA,PCA,PICA和右MCA中较高的CBF与AMS发展相关.
- 在男性中,右PCA CBF显示了最高的预测值 (AUC=0.818);在女性中,ACA LI预测了AMS (AUC=0.753).
结论:
- 海平面CBF,特别是在后部循环中,可能预测男性志愿者的AMS.
- 非侵入性3D-pCASL是评估AMS风险的一个有希望的工具.
- CBF横向性也可能在AMS预测中发挥作用,特别是在女性中.
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