相关实验视频

Updated: Jun 14, 2025

Cerebellar Regional Dissection for Molecular Analysis

Cerebellar Regional Dissection for Molecular Analysis

Published on: December 5, 2020

2,3和10型脊髓脑动症患者的多神经病变:一个系统性审查

André Eduardo de Almeida Franzoi¹, Gustavo Figueiredo da Silva², Eduardo de Souza Somensi³

¹Department of Internal Medicine, Neurology Service, Hospital de Clínicas, Federal University of Paraná, Curitiba, Paraná, Brazil. andrefranzoi@hotmail.com.

Cerebellum (London, England)

|August 28, 2024

概括

这份综述表明,在2型和3型脊髓脑缩症 (SCA) 中出现了外围神经病变. 需要更多的研究来确认SCA类型2,3和10中的多神经病变.

科学领域:

神经科学是一个神经科学.
遗传学遗传学是一个
神经学神经学

背景情况:

脊髓脑衰 (SCA) 涵盖了50多种自体主导的神经退行性疾病.
瘤表现出不同的表型,进展率和临床严重程度.
周围神经病变是某些神经退行性疾病的潜在表现.

研究的目的:

系统地审查关于脊椎脑尾性的多神经病特征的文献,类型为2,3,和10.
确定有关这些SCA亚型中外围神经病变的现有证据和知识差距.

主要方法:

使用相关关键词进行系统的文献审查.
数据库搜索产生了16,972篇文章;在选和全文审查后,包括了24项研究.
分析的重点是对SCA类型2,3和10中外围神经病变的描述.

主要成果:

有证据表明,在2型和3型脊髓脑缩症中,外围神经病变,可能是多神经病变.
对于SCA类型10存在有限的数据,只有一个病例系列表明外围神经病变.
在CAG重复长度,SARA得分和外围神经病变之间的关联需要进一步调查.

结论:

在SCA类型2和3中建议进行外围神经病变,因此需要进一步研究.
由于数据稀缺,SCA类型10中外围神经病变的存在仍然不确定.
未来的研究应该专注于确认这些SCA类型中的多神经病变,并探索基因型-表型相关性.

关键词:

电子神经机械图谱是一种电子神经机械图谱.周围神经病变是一种神经病变.多性神经病变 (Polyneuropathy) 是一种多性神经病变.脊髓大脑小骨性动脉衰竭

更多相关视频

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia

Published on: May 21, 2010

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration

Published on: June 15, 2018

相关概念视频

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...