探索没有冷保护剂的班达纳米颗粒的溶解,固态特性和长期储存稳定性
Giselle Bedogni1, Lina Vargas Michelena1, Katia Seremeta2,3
1Instituto de Química Rosario, Consejo Nacional de Investigaciones Científicas y Técnicas (IQUIR-CONICET), Suipacha 531, Rosario, 2000, Argentina.
AAPS PharmSciTech
|August 28, 2024
概括
这项研究使用Poloxamers开发了fenbendazole纳米颗粒,以提高药物的溶解性和溶解性. 由此产生的纳米颗粒证明了药物释放的改善,为班达输送提供了一个有前途的纳米技术方法.
科学领域:
- 制药纳米技术 制药纳米技术
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 班达是一种抗寄生虫药物,在癌症治疗中具有潜力,但具有不良的溶解性.
- 疏水性限制了班达的溶解速度和吸收,阻碍了其治疗效果.
- 纳米技术提供了一种策略,以克服班达的溶解性挑战.
研究的目的:
- 通过纳米技术方法改善班达的溶解性和溶解性能.
- 为了配制由波洛克萨默斯稳定的班达纳米粒子.
- 为了评估fenbendazole纳米系统的物理化学特性和稳定性.
主要方法:
- 班达纳米颗粒通过冷制备,使用各种波洛克萨默作为稳定剂.
- 固态特征包括X射线衍射测量,微分扫描热量测量和红外光谱学.
- 评估了可溶性,溶解率,颗粒大小,多分散性和长期稳定性.
主要成果:
- 纳米粒子表现出亚微米大小 (<340nm) 的低多分散性,受波洛克萨默稳定剂的影响.
- 物理化学分析显示了药物的显著无形化,增强了溶解性和溶解性.
- 新鲜和老化的纳米颗粒的溶解率明显高于原始药物.
- 波洛克萨默407稳定纳米粒子在三年内显示出良好的粒子大小稳定性.
- 在长期储存期间,在P188,P237和P407稳定的纳米粒子中发生了一些再结晶.
结论:
- 波洛克萨默斯有效地稳定了班达纳米颗粒,显著改善了药物的溶解.
- 纳米系统内班达的变态化是提高溶解度和释放的关键.
- 波洛克萨默407在长时间内保持纳米粒子稳定性方面表现出卓越的性能.
- 这些发现突显了基于波洛克萨默的纳米系统在改善班达输送方面的潜力.
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