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Updated: Jun 14, 2025

A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery
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A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery

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调整B-CLL微环境:证据表明BAG3蛋白介导调节树突纤维细胞活动

Anna Basile1, Valentina Giudice2,3, Laura Mettivier3

  • 1Department of Sanitary Hygiene and Evaluative Medicine U.O.C. Clinical and Microbiological Pathology, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Salerno, Italy.

Cell death discovery
|August 28, 2024
PubMed
概括

流体纤维细胞中的Bcl2-关联的亚桑基-3 (BAG3) 蛋白促进B细胞慢性淋巴细胞白血病 (B-CLL) 的存活率. 沉默BAG3会破坏促生存信号和细胞因子网络,为CLL提供新的治疗点.

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