维生素E,维生素B6和维生素B12与冠心病的相关性
Boyu Li1, Mengjin Hu2, Yuanliang Ma2
1Department of Cardiology, Xuanwu Hospital Capital Medical University, Beijing, China. sucess20231008@163.com.
Scientific reports
|August 28, 2024
概括
维生素E和维生素B6对冠心病 (CHD) 具有保护作用,特别是在女性,肥胖者和吸烟者身上. 维生素B12与心脏病风险的相关性很小.
科学领域:
- 营养科学 营养科学
- 心血管健康 心血管健康
- 流行病学 流行病学
背景情况:
- 关于维生素B12在冠心病 (CHD) 中的作用存在相互矛盾的证据.
- 之前的研究没有同时检查与心脏病相关的维生素E,B6和B12.
- 需要大规模的人口数据来澄清这些关联.
研究的目的:
- 调查维生素E,B6和B12摄入量与冠心病 (CHD) 患病率之间的关联.
- 为了确定特定的人口亚群,他们可能会从这些维生素摄入中获益最多,关于心脏病风险.
- 澄清这些维生素对心血管健康的独立和联合作用.
主要方法:
- 利用了2003-2020年国家健康和营养检查调查 (NHANES) 的数据,其中包括33,640名参与者.
- 采用多变量逻辑回归和子组分析来评估维生素摄入百分比与慢性病之间的关系.
- 控制了各种人口,生活方式和健康因素,包括年龄,BMI,性别,吸烟和糖尿病状况.
主要成果:
- 维生素E和维生素B6摄入量与心脏病有显著的负相关性,表明有保护作用.
- 在这项研究中,维生素B12与心脏病发病率的相关性很小.
- 对维生素E和维生素B6的最强的保护作用是在摄入的第三四分位数中观察到的,对女性,BMI为25-30的个体和吸烟者有显著影响.
结论:
- 维生素E和维生素B6可能对冠心病 (CHD) 有保护作用.
- 这些保护作用在特定的子组中显得更加明显:女性,BMI在25-30 (超重/肥胖) 之间的个体和目前的吸烟者.
- 进一步的研究应该考虑这些维生素,特别是E和B6,在心血管健康策略中,承认社会经济因素的潜在影响.
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