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Evaluation of the Storage Stability of Extracellular Vesicles
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在储存期间评估雷曼尼亚衍生的纳米的稳定性和生物活性
Xiaohang Chen1,2, Lianghang He1,2, Yao Chen1
1Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.
Scientific reports
|August 28, 2024
概括
在不同温度下储存植物衍生纳米纤维 (PDNVs) 会影响它们的稳定性和生物活性. 快速冷后的-80°C存储最好保存抗迁移活性,这表明需要新型保护剂.
科学领域:
- 生物医学科学 生物医学科学
- 纳米技术纳米技术
- 植物生物技术 植物生物技术
背景情况:
- 由于丰富的RNA,蛋白质,脂质和代谢物含量,植物衍生纳米纤维 (PDNV) 越来越被认为具有生物医学潜力.
- 有效保存PDNV对于实验可重现性和临床转换至关重要.
研究的目的:
- 研究不同储存温度对雷曼尼亚衍生纳米纤维 (RDNVs) 的稳定性和生物活性的影响.
主要方法:
- 在各种温度条件下储存RDNV.
- 随着时间的推移,评估了粒子大小,溶液潜力,聚合,细胞增殖抑制和抗迁移活性.
主要成果:
- 在两周内,RDNVs在4°C时显示聚合和增加颗粒大小/溶液潜力.
- 所有储存温度都导致两个月后不同程度的聚合.
- 细胞增殖抑制生物活性随着时间的推移而下降,而快速结之后的-80°C储存与直接的-80°C储存相比,更好地保留了抗迁移活性.
结论:
- 仅仅温度就不足以维持RDNV的稳定性和生物活性.
- 新的保护剂是必要的,以提高植物衍生的纳米的保存.
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