组织学改善预测性结肠炎患者内镜缓解
Ji Eun Kim1, Minjee Kim1, Min-Ji Kim2
1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
组织学改善预测性结肠炎 (UC) 患者的内镜缓解,其内镜得分较低. 实现组织学改善可以降低UC临床复发的可能性.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 临床病理学 临床病理学
背景情况:
- 组织学改善是性结肠炎 (UC) 内镜缓解的潜在预后因素.
- 关于内镜缓解的组织学活性对UC患者内镜分数低的内镜缓解的预测价值的研究有限.
研究的目的:
- 评估组织学活性是否预测UC患者内镜缓解,梅奥内镜子底值 (MES) 为0或1.
- 为了比较具有组织学改善的患者和具有活跃组织学疾病的患者之间的临床结果.
主要方法:
- 在2018年1月至2020年12月期间,对492名UC患者的MES0或1进行了回顾性分析.
- 分类为两个队列:组织学改善和活跃的组织学疾病.
- 在随访期间评估内镜活动,主要结局是基于组织学活动的内镜缓解.
主要成果:
- 组织学改善的患者比具有活跃组织学的患者更有可能实现内镜缓解.
- 活跃组织学组具有更高的临床复发的可能性.
- 在最初的随访期间评估了435名患者的内镜活动,并在随后的随访期间评估了146名患者.
结论:
- 组织学改善是UC患者内镜缓解的重要预测因子,其内镜评分较低 (MES 0-1).
- 维持组织学改善与UC临床复发风险较低有关.
- 组织学评估对于预测治疗反应和UC管理中的临床结果非常有价值.
更多相关视频
15:49Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
Published on: October 16, 2013
09:42Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
Published on: August 26, 2014
相关概念视频
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Drugs for Treatment of Ulcerative Colitis in IBD
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
