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相关概念视频

Strain and Elastic Modulus01:15

Strain and Elastic Modulus

The quantity that describes the deformation of a body under stress is known as strain. Strain is given as a fractional change in either length, volume, or geometry under tensile, volume (also known as bulk), or shear stress, respectively, and is a dimensionless quantity. The strain experienced by a body under tensile or compressive stress is called tensile or compressive strain, respectively. In contrast, the strain experienced under bulk stress and shear stress is known as volume and shear...
Problem Solving on Stress and Strain01:22

Problem Solving on Stress and Strain

Stress is a quantity that describes the magnitude of a force that causes deformation, generally defined as internal force per unit area. When forces pull on an object and cause its elongation, like the stretching of an elastic band, it is called tensile stress. When forces cause the compression of an object, it is known as compressive stress. When an object is being squeezed uniformly from all sides, like a submarine in the depths of the ocean, we call this kind of stress bulk stress (or volume...
Hooke's Law01:26

Hooke's Law

Hooke's law, a pivotal principle in material science, establishes that the strain a material undergoes is directly proportional to the applied stress, defined by a factor called the modulus of elasticity or Young's modulus.
Plastic Behavior01:21

Plastic Behavior

A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and reloaded.
Generalized Hooke's Law01:22

Generalized Hooke's Law

The generalized Hooke's Law is a broadened version of Hooke's Law, which extends to all types of stress and in every direction. Consider an isotropic material shaped into a cube subjected to multiaxial loading. In this scenario, normal stresses are exerted along the three coordinate axes. As a result of these stresses, the cubic shape deforms into a rectangular parallelepiped. Despite this deformation, the new shape maintains equal sides, and there is a normal strain in the direction of the...
Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity01:15

Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity

Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.

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An Efficient and Flexible Cell Aggregation Method for 3D Spheroid Production
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细胞球形粘弹性是变形依赖的.

Ruben C Boot1, Anouk van der Net2, Christos Gogou2

  • 1Department of Chemical Engineering, Delft University of Technology, Delft, 2629, HZ, The Netherlands.

Scientific reports
|August 28, 2024
PubMed
概括

细胞球体显示表面张力,这取决于它们的变形程度. 这挑战了表面张力总是随着生物组织中施加的力而增加的想法.

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科学领域:

  • 生物物理学的生物物理.
  • 细胞生物学 细胞生物学
  • 组织工程是组织工程.

背景情况:

  • 组织表面张力对于细胞分类和融合至关重要.
  • 之前的研究表明,多细胞球体在施加力下积极增强表面张力.

研究的目的:

  • 调查力持续时间和球状形状变形性对组织表面张力的作用.
  • 确定表面紧张强化是否在不同的施加力中一致.

主要方法:

  • 使用高吞吐量微流体微管吸收.
  • 测量了NIH3T3和HEK293T细胞球体的粘弹性爬行行为.
  • 多种应用压力和监测细胞收缩动态.

主要成果:

  • 较大的球形变形与更快的细胞收缩后压力释放相关.
  • 不太容易变形的NIH3T3球体 (具有更高的α-平滑肌肉活性) 在较小的变形时显示出更慢的收缩速度.
  • 尽管粘度增加了,但HEK293T球体仅在更高的压力和变形下表现出收缩.

结论:

  • 球体粘弹性取决于变形.
  • 在更大的吸入压力下,表面张力的增强是有问题的.
  • 这些发现挑战了现有的组织力学和表面张力动态模型.