Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Molecular Models02:00

Molecular Models

38.1K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
38.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

ATPγS substantially defeats the biasing mechanism for kinesin steps.

Nature communications·2026
Same author

Hub stability in the calcium calmodulin-dependent protein kinase II.

Communications biology·2024
Same author

Real-time single-molecule imaging of CaMKII-calmodulin interactions.

Biophysical journal·2024
Same author

Single-molecule force spectroscopy reveals binding and bridging dynamics of PARP1 and PARP2 at DNA double-strand breaks.

Proceedings of the National Academy of Sciences of the United States of America·2023
Same author

Altered Storage and Function of von Willebrand Factor in Human Cardiac Microvascular Endothelial Cells Isolated from Recipient Transplant Hearts.

International journal of molecular sciences·2023
Same author

Analysis of Plasmodium falciparum myosin B ATPase activity and structure in complex with the calmodulin-like domain of its light chain MLC-B.

The Journal of biological chemistry·2022

相关实验视频

Updated: Jun 14, 2025

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

8.5K

虚拟细胞中的单分子动力学结合了3维矩阵模型和随机步行.

Gregory I Mashanov1, Justin E Molloy2,3

  • 1The Francis Crick Institute, London, NW1 1AT, UK. gregory.mashanov@crick.ac.uk.

Scientific reports
|August 28, 2024
PubMed
概括

这项研究介绍了一种3D细胞模拟工具,用于模拟单个分子的行为. 它生成现实的视频,用于与活细胞显微镜进行比较,从而推进细胞生物学研究.

科学领域:

  • 细胞生物学 细胞生物学
  • 计算生物学 计算生物学
  • 生物物理学的生物物理.

背景情况:

  • 光显微镜使单分子成像在活细胞中,影响细胞生物学.
  • 计算机建模有助于实验解释和假设生成.
  • 当前的模型经常使用简化的系统,限制了现实主义.

研究的目的:

  • 开发一种3D模拟工具,用于对细胞结构内的分子动力学进行现实的建模.
  • 为了弥合计算模型和实验光显微镜数据之间的差距.

主要方法:

  • 分子运动和相互作用的面向对象计算机建模.
  • 一个包括亚细胞结构的3D发声细胞表示.
  • 数字模拟成千上万个单个分子的浮点精度.

主要成果:

  • 模拟工具创建单个光体强度的现实时间序列视频.
  • 模拟视频包括现实的背景噪音,模仿实验数据.
  • 该工具可以直接比较模拟和实验光显微镜数据.

结论:

  • 这种3D模拟工具增强了单分子显微镜实验的解释能力.

更多相关视频

Author Spotlight: Streamlining Visual Dynamics to Simplify Molecular Dynamics Simulations Using Gromacs
05:00

Author Spotlight: Streamlining Visual Dynamics to Simplify Molecular Dynamics Simulations Using Gromacs

Published on: August 9, 2024

1.2K
Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules
00:10

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules

Published on: September 5, 2019

8.2K

相关实验视频

Last Updated: Jun 14, 2025

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

8.5K
Author Spotlight: Streamlining Visual Dynamics to Simplify Molecular Dynamics Simulations Using Gromacs
05:00

Author Spotlight: Streamlining Visual Dynamics to Simplify Molecular Dynamics Simulations Using Gromacs

Published on: August 9, 2024

1.2K
Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules
00:10

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules

Published on: September 5, 2019

8.2K
  • 它为生成和测试细胞生物学假设提供了一个强大的平台.
  • 这种方法有助于更准确地了解复杂的细胞环境中的分子行为.