在紧急情况下服用家庭纳洛:在集群随机试验中实施干预的可行性
Helen A Snooks1, Jenna K Jones2, Fiona B Bell3
1Swansea University, Swansea, UK. H.A.Snooks@Swansea.ac.uk.
BMC emergency medicine
|August 28, 2024
概括
这项研究评估了英国紧急情况中带回家纳洛 (THN) 计划的可行性. 招募率低,现场表现多样,这意味着该干预措施不符合更大的试验的进展标准.
科学领域:
- 紧急医疗 紧急医疗
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 过量服用阿片类药物是与药物相关的死亡的主要原因.
- 纳洛是逆转过量药物的关键阿片类抗体.
- 拿回家的纳洛 (THN) 套件提供了同行管理的干预.
研究的目的:
- 评估在英国紧急部门和救护车服务中实施带回家的纳洛 (THN) 干预措施的可行性.
- 在紧急情况下为THN分发提供最终随机对照试验 (RCT) 的设计提供信息.
主要方法:
- 一个集群的随机对照试验 (RCT) 在英国的紧急部门 (ED) 和救护车服务中进行.
- 紧急医疗保健从业人员接受了培训,为患有阿片类药物过量或相关疾病的患者提供THN套件.
- 根据预先定义的标准评估可行性,包括人员培训,患者识别,试剂盒发行和不良事件.
主要成果:
- 在两个干预地点,培训达到43.5%的临床工作人员.
- 只有60个THN套件被提供给符合条件的患者 (21.7%的确诊病例).
- 不发行套件的常见原因包括员工忘记 (136例) 和员工过于忙 (15例). 没有报告任何严重的不良事件.
结论:
- 可行性研究表明,各站点的员工和患者招聘率低和高度变化.
- 该干预措施没有满足预先确定的进展标准.
- 基于这些发现,没有计划进行全功率随机对照试验 (RCT).
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