无抗炎药,止痛药,抗血小板药和功能下降:通过SIDIAP数据库进行回顾性病例对照研究
Sara Bonet-Monné1,2, Cristina Vedia Urgell2,3, M José Pérez Sáez4
1Servei d'Atenció Primària Baix Llobregat Centre, Institut Català de la Salut, Cornellà de Llobregat, Spain.
BMC pharmacology & toxicology
|August 28, 2024
概括
某些药物,如甲米醇和抗血小板药物,特别是triflusal,与功能下降有关. 高度使用特定的非类固醇抗炎药物 (NSAID) 和阿片类药物也对脏健康构成风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 调查常见药物类别对功能影响对于患者安全至关重要.
- 估计的淋巴膜过率 (eGFR) 是脏健康的关键指标.
- 了解与药物相关的衰退有助于预防策略.
研究的目的:
- 为了检查NSAIDs,SYSADOA,止痛药和抗血小板药物的消费与功能下降之间的关联.
- 确定与降低EGFR相关的特定药物类型和使用模式.
主要方法:
- 在使用加泰罗尼亚的SIDIAP数据库进行了一项病例控制研究.
- 病例被定义为具有显著EGFR下降的患者 (eGFR ≤45毫升/分钟/1.73米2).
- 对照组具有稳定或正常的eGFR (eGFR ≥60毫升/分钟/1.73米2),符合关键的人口和临床因素. 后勤回归模型被用来估计在定义的每日剂量 (DDD) 中对药物消费进行调整的几率比率 (OR).
主要成果:
- 甲米醇和抗血小板药物显示功能下降的风险增加.
- 高剂量的酸衍生物和Coxibs (NSAIDs) 与更高的风险相关.
- 中等到高水平使用主要阿片类药物也存在重大风险.
- 抗血小板剂Triflusal在中高水平使用时表现出特别高的风险.
结论:
- 甲米醇,抗血小板药物 (尤其是triflusal),高剂量的NSAIDs (酸衍生物,Coxibs) 和主要阿片类药物与功能下降有关.
- 这些发现强调了使用这些药物的患者监测功能的重要性.
- 需要进一步的研究来证实这些关联并探索潜在的机制.
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