在全球海洋中编码的 Prokaryotic 病毒辅助代谢基因遍布全球海洋
Funing Tian1,2,3, James M Wainaina1,2,4, Cristina Howard-Varona1,2
1Department of Microbiology, Ohio State University, Columbus, OH, 43210, USA.
Microbiome
|August 28, 2024
概括
病毒通过编码辅助代谢基因 (AMG) 来显著影响海洋生物地化学循环. 这项研究对这些病毒基因进行了目录,揭示了它们的广泛存在以及它们在微生物新陈代谢和海洋过程中的关键作用.
科学领域:
- 海洋微生物学 海洋微生物学
- 病毒学 病毒学
- 生物地质化学生物地质化学
背景情况:
- Prokaryotic 微生物和病毒是海洋生物地球化学循环的关键驱动因素.
- 病毒通过溶解,基因转移和宿主细胞的代谢重编程来影响这些循环.
- 量化病毒影响是具有挑战性的,需要对病毒编码的辅助代谢基因 (AMG) 进行分析.
研究的目的:
- 系统地开发一个全球海洋AMG目录.
- 将这些AMG置于与海洋生物地球化学相关的生态和代谢背景中.
- 了解病毒在调节全球海洋代谢中的作用.
主要方法:
- 从塔拉海洋的元基因组数据中整合了以前描述的和新发现的AMG.
- 从超过579,904个已识别的海洋病毒种群中目录了86,913个AMG.
- 将AMG映射到340个微生物代谢途径中,以确定目标"热点".
主要成果:
- 从579904个海洋病毒种群中确定了86,913个AMG,其中32%是新报告的.
- 据估计,19%的海洋病毒种群至少携带一个AMG.
- 发现AMG映射到128个代谢途径,其中碳水化合物,氨基酸,脂肪酸和核酸代谢的显著向.
结论:
- 一个系统地策划的全球海洋AMG目录提供了对海洋新陈代谢中的病毒作用的基础见解.
- 病毒通过其编码的辅助代谢基因积极调节关键的生物地化学过程.
- 该资源有助于了解病毒对海洋生态系统的重大,但往往未定量的影响.
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