围产期逆境作为一种共同因素,是非典型横向性和神经发育障碍之间的关联的基础:一种发育视角
Jad Hamaoui1,2, Sebastian Ocklenburg3,4,5, Hervé Segond6
1Azrieli Research Center of Sainte-Justine University Hospital, Montreal, Quebec, Canada.
Psychophysiology
|August 29, 2024
概括
围产期的逆境可能会破坏神经发育和非典型的横向性,因为它会影响下丘脑-垂体-上腺 (HPA) 轴和前置系统. 了解发育轨迹是解释非典型手性与神经发育障碍之间的联系的关键.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 遗传学 遗传学 是一个
背景情况:
- 非典型的横向性,如左撇子,在神经发育障碍中更为常见.
- 这种关联的神经生物学基础,涉及遗传和非遗传因素,仍然不清楚.
- 新兴研究将由下丘脑-垂体-上腺 (HPA) 轴调节的压力与侧面性发展联系起来.
研究的目的:
- 提出一个理论框架,将围产期逆境与非典型的横向性和神经发育障碍联系起来.
- 探索HPA轴和前置系统在这种协会中的潜在作用.
- 强调考虑发育轨迹的重要性,而不是简单的因素诊断链接.
主要方法:
- 现有研究的理论审查和综合.
- 开发一个概念模型,整合围产期因素,HPA轴,前体系统,横向性和神经发育.
- 确定研究缺口和未来方向.
主要成果:
- 围产期的逆境可能会扰乱神经发育轨迹和横向性.
- HPA轴和前庭系统是围产期压力和异常发育之间的关系的潜在调解者.
- 从发展的角度来看,对于理解因素的复杂相互作用至关重要.
结论:
- 提出了一个理论框架,表明围产期逆境如何通过HPA轴和前庭系统影响神经发育和侧面性.
- 这项研究强调了需要考虑与非典型横向性相关的神经发育障碍的发展途径.
- 未来的研究应该调查这些拟议的机制和发展轨迹.
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