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PARP 抑制剂耐药性机制和 PARP 抑制剂衍生成像探针

Tony Yu1, Benjamin H Lok1,2,3,4

  • 1Department of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Expert review of anticancer therapy
|August 29, 2024
PubMed
概括

多种 (ADP-ribose) 聚合酶1 (PARP1) 抑制剂在癌症治疗中表现有前途. 开发成像生物标志物对于患者选择和克服对PARP抑制剂 (PARPi) 的耐药性至关重要.

关键词:
造成的DNA损伤是DNA损伤.在 PARP 抑制剂.生物标志物 生物标志物癌症治疗疗法 癌症治疗分子成像分子成像技术电阻的电阻是指电阻的电阻敏感化 敏感化这就是神经预知学.

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Labeling DNA Probes03:31

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...