补充阿斯塔山丁并没有改变与训练相关的阿拉伯赛马炎症性细胞因子轮的变化
Beata Giercuszkiewicz-Hecold1, Marek Kulka2, Michał Czopowicz3
1Doctoral School, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159c, 02-776 Warsaw, Poland.
Antioxidants (Basel, Switzerland)
|August 29, 2024
概括
口服阿斯塔克桑 (ATX) 补充剂在训练期间没有显著改变阿拉伯赛马的炎症标志物或性能. 然而,定期炼自然会降低关键的炎症性细胞因子,这表明训练训练.
科学领域:
- 马体育医学 马体育医学
- 营养生物化学 营养生物化学
- 运动生理学 运动生理学
背景情况:
- 阿斯塔丁 (ATX) 在体外和人类研究中表现出抗氧化和抗炎性质.
- 有限的数据存在于马体育运动员的ATX影响.
- 了解ATX对赛马的影响对于性能和健康管理至关重要.
研究的目的:
- 评估口服阿斯塔克桑 (ATX) 补充剂对阿拉伯赛马炎症标志物的疗效.
- 评估ATX在比赛训练期间对细胞因子 (TNFα,IFNγ,IL-6,IL-10,PGE) 的影响.
- 为了确定ATX补充是否会影响赛马的血液学参数或运动表现.
主要方法:
- 一个受控的试验涉及14匹阿拉伯赛马在四个月的训练中.
- 马匹补充了ATX (n=6) 或安慰剂 (n=8).
- 每月对炎症性细胞因子,血液学参数和性能指标进行测量.
主要成果:
- 在ATX和安慰剂组之间没有观察到测量炎症性细胞因子或性能的显著差异.
- 在两组中都发现了TNFα和IFNγ水平的显著时间依赖性下降,这归因于训练.
- 在不同研究阶段确定了特定细胞因子对 (TNFα/IFNγ和IL-6/IL-10) 之间的正相关性.
结论:
- 在这种阿拉伯赛马队列中,口服阿斯塔克桑补充剂对炎症标志物或运动表现没有显著的益处.
- 定期的比赛训练本身具有固有的抗炎作用,调节细胞因子水平.
- 需要进一步的研究来研究在各种条件下ATX的疗效,例如在患有亚临床炎症或不同的训练方案的马匹中.
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