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在MASLD中改变了线粒体功能:关键特征和有前途的治疗方法
Tatjana Radosavljevic1, Milica Brankovic2, Janko Samardzic2
1Institute of Pathophysiology "Ljubodrag Buba Mihailovic", Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Antioxidants (Basel, Switzerland)
|August 29, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 涉及线粒体功能障碍,影响肝脏健康. 增强线粒体功能为MASLD和代谢相关脂肪肝炎 (MASH) 提供了一个有前途的治疗途径.
科学领域:
- 肝病学和代谢障碍 肝病和代谢障碍
- 线粒体生物学和疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为非酒精性脂肪性肝病 (NAFLD),是一种肝病的范围,其全球流行率越来越高,特别是在代谢综合征患者中.
- MASLD的发病涉及复杂的因素,包括代谢失调,炎症,氧化应激,遗传倾向,以及关键的线粒体功能障碍.
研究的目的:
- 阐明线粒体功能障碍在MASLD进展中的关键作用.
- 探索针对MASLD和代谢相关脂肪肝炎 (MASH) 治疗的线粒体功能的新和现有治疗策略.
主要方法:
- 综述最近的科学文献,重点关注MASLD病原和线粒体功能障碍.
- 治疗干预的分析,包括生活方式的修改,药理学剂,和新兴的策略,如基因编辑.
主要成果:
- 线粒体功能障碍是MASLD从肥胖症进展到MASH等更严重形式的关键驱动因素.
- 线粒体功能的治疗增强,以及生活方式的改变,显示了MASLD管理的前景.
- 美国食品和药物管理局批准了resmetirom用于纤维化MASH,这意味着治疗进步.
结论:
- 更深入地了解与MASLD相关的线粒体功能障碍对于开发有效的治疗方法至关重要.
- 需要创新方法,包括药物重新定位和针对新途径,以应对日益增长的全球MASLD负担.
- 涉及生活方式干预和向治疗的联合策略有可能改善患者的治疗结果.
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