一个系统的审查在管理氧化应激相关心血管疾病的进展
Soyeon Jin1,2, Peter M Kang1
1Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, 3 Blackfan Circle, CLS 910, Boston, MA 02215, USA.
控制氧化应激对于心血管健康至关重要. 本综述探讨了预防和治疗与氧化应激有关的心脏病的补充剂,药品和生物标志物.
科学领域:
- 心脏病学 心脏病学
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 氧化应激是诸如动脉样硬化和心力衰竭等心血管疾病的关键因素.
- 需要有效的管理策略来减轻心血管风险.
研究的目的:
- 系统地审查目前对心血管疾病的氧化应激管理方法.
- 整合最近关于补充剂,药理疗法和生物标志物的发现.
主要方法:
- 使用特定关键词对PubMed的系统文献搜索.
- 重点是最近的,具有重大影响力的出版物.
- 对200篇精选文章的审查.
主要成果:
- 补充剂 (白醇,维生素C/E,欧米茄-3,黄类,CoQ10) 显示出抗氧化和心血管方面的益处.
- 新型抗氧化剂,纳米颗粒和药理学剂针对特定的氧化应激途径.
- 生物标志物 (sTfR,TTR,cystatin C) 有助于评估抗氧化剂状况和心血管风险.
结论:
- 保持氧化剂-抗氧化剂平衡对于心血管疾病的进展至关重要.
- 本综述强调了心脏病学中氧化应激管理的各种策略.
- 已注册的系统审查 (INPLASY# INPLASY202470064) 进行.
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