聚乙烯是一种白醇衍生物,通过通过增加SIRT1/Nrf2表达来提高老化的抗氧化防御来改善卵巢功能
Xinyu Wang1, Qiongyu Yuan1, Yingyu Xiao1
1Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Antioxidants (Basel, Switzerland)
|August 29, 2024
概括
固醇 (PTS),一种天然的抗氧化剂,通过减少卵巢氧化应激,显著提高产母的性能. 这种天然化合物增强抗氧化能力,改善脂肪代谢,调节细胞亡,导致卵子产量增加.
科学领域:
- 禽畜科学 禽畜科学 禽畜科学
- 动物营养 动物营养
- 氧化压力研究研究 氧化压力研究
背景情况:
- 氧化应激会导致母的卵泡衰减和卵巢衰老,降低产卵性能.
- 减少氧化应激对于改善卵巢功能和延长家禽产卵期至关重要.
研究的目的:
- 研究天然抗氧化剂 (PTS) 对低产的卵巢氧化应激的影响.
- 评估PTS对老产卵率,抗氧化能力,亡和脂肪代谢的影响.
主要方法:
- 三十六只Hy-Line White产卵被分为四组,并在15天内食不同剂量的PTS.
- 评估产卵率,卵巢和肝脏抗氧化酶水平 (谷氨,GPx,SOD,CAT),血清抗氧化能力,与亡相关的基因表达 (Bax,Caspase-3,γ-H2AX,BCL-2),以及脂肪代谢指标.
- 通过使用D-银糖诱导的小白毛囊进行了体外实验,以通过SIRT1/Nrf2通路检查PTS的机制.
主要成果:
- 食PTS补充剂显著增加了产卵率,最高增加了42.7%.
- PTS增强了卵巢,肝脏和血清的抗氧化能力,减少了亲亡标记物和增加了抗亡标记物.
- PTS减少了腹部脂肪的积累,并促进了脂肪转移到卵巢,而体外研究表明PTS调节了SIRT1/Nrf2的表达,以恢复抗氧化能力.
结论:
- 固醇 (PTS) 有效地减轻老龄化产母的氧化压力,改善卵巢功能和提高产母性能.
- PTS调节细胞亡和脂肪代谢,可能通过SIRT1/Nrf2通路,为家禽生产挑战提供自然解决方案.
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