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素通过调节结肠微生物群来调节肝脏和肠道炎症和氧化应激

Xiaotong Pang¹, Xin Wei¹, Yanyan Wu¹

¹College of Animal Science and Technology, Shihezi University, Shihezi 832000, China.

Antioxidants (Basel, Switzerland)

|August 29, 2024

概括

素 (CAP) 减少炎症和氧化应激在与脂多糖 (LPS) 挑战的小鼠. 此外,CAP还调节肠道微生物群,这表明在炎症条件下具有潜在的治疗益处.

科学领域:

胃肠病学胃肠病学
免疫学免疫学免疫学
微生物学微生物学

背景情况:

脂聚糖 (LPS) 是肝脏和肠道中炎症和氧化应激的强有力的诱导剂.
的活性成分素 (CAP) 具有已知的抗炎和抗氧化特性.
CAP对LPS诱导的肠道失生症的影响及其对结肠微生物群的具体影响尚未完全阐明.

研究的目的:

在小鼠模型中研究素对脂聚糖诱导的肝脏和肠道炎症以及氧化应激的保护作用.
在LPS诱导的炎症的背景下分析素对结肠微生物群的调节.
探索素的抗炎和抗氧化作用及其对肠道微生物群组成的影响之间的关系.

主要方法:

30只雄性昆明小鼠被分为三个组:对照组,LPS诱导组和LPS+CAP组.
小鼠每天接受28天的正常盐水或素治疗,然后在各自的组中注射LPS.
进行了组织学分析,细胞因子水平测量 (IL-10,IL-6,IL-1β,TNF-α),氧化应激标志物 (CAT,GSH-Px,SOD,MDA) 和16SrRNA基因测序以分析肠道微生物群.

主要成果:

CAP的使用显著改善了LPS诱导的肝损伤和改善了十二指甲状腺形态.
在肝脏和结肠中,CAP治疗增加了抗炎性细胞因子IL-10,同时降低了促炎性细胞因子IL-6,IL-1β和TNF-α.
在肝脏中,CAP增强了抗氧化酶表达 (CAT,GSH-Px,SOD) 和降低了脂质过氧化 (MDA). 它还改变了特定肠道细菌的相对丰富性,包括 *Mucispirillum *和 *Helicobacter * 的增加.
除了酸之外,CAP总体减少了短链脂肪酸.

结论:

素在LPS诱导的小鼠模型中显示出显著的抗炎和抗氧化作用,保护肝脏和肠道组织.
CAP调节结肠微生物群,可能有助于其治疗效果,显著增加了*Mucispirillum*和*Helicobacter*物种.
需要进一步的研究来证实CAP诱导的微生物群变化的因果作用,特别是Mucispirillum和Helicobacter在调解其抗炎和抗氧化功效方面.

关键词:

卡普赛辛是一种素.在这里,我们可以看到子子.这是一种炎症炎症炎症炎症.我们的肠道微生物群.肝脏肝脏肝脏肝脏肝脏肝脏氧化应激是一种氧化应激.

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