有氧运动与非侵入性脑刺激对多发性硬化症认知功能的影响:系统性审查和元分析
Mahmoud Elkhooly1, Arianna Di Stadio2,3, Evanthia Bernitsas4
1Department of Neurology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA.
Brain sciences
|August 29, 2024
概括
非侵入性脑刺激 (NIBS) 和有氧运动或联合炼在患有多发性硬化症 (pwMS) 的患者中有望改善认知能力. 对于其他运动类型,需要进一步的研究.
科学领域:
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
- 临床试验 临床试验
背景情况:
- 认知障碍是多发性硬化症 (pwMS) 患者的一个重大挑战.
- 非侵入性脑刺激 (NIBS) 和运动是解决pwMS认知缺陷的潜在干预措施.
研究的目的:
- 评估非侵入性脑刺激 (NIBS) 和各种运动方式在患有多发性硬化症 (pwMS) 患者的认知功能上的疗效.
主要方法:
- 在主要数据库 (Cochrane Library,Scopus,PubMed,Web of Science) 进行了全面的文献搜索,截至2024年2月.
- 来自12项涉及208 pwMS的NIBS研究和26篇涉及708 pwMS的运动干预措施的文章的数据被选和提取.
主要成果:
- 在12项研究中的7项中,非侵入性脑刺激 (NIBS) 在改善反应时间,注意力和处理速度方面被发现有效.
- 有氧运动在十项研究中证明了提高认知领域的有效性,而抵抗运动在三项研究中显示了益处.
- 在调查它的单一研究中没有产生显著的认知改善.
结论:
- 非侵入性脑刺激 (NIBS) 是一种潜在的途径,可以提高多发性硬化症 (pwMS) 患者的认知能力.
- 有氧和联合炼方案经常被研究,并且似乎有效改善pwMS的认知能力.
- 需要进一步研究阻力,平衡和伸展炼对这一群体认知功能的影响.
相关概念视频
Long-term Depression
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Calcium Ion Concentration Mechanism
If over time, all...
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function. They...
Hepatic Encephalopathy
DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...


