在手术前的水缩预测了接受机器人辅助激进囊切除术的患者的结果
Chris Ho-Ming Wong1, Ivan Ching-Ho Ko1, David Ka-Wai Leung1
1S.H. Ho Urology Centre, Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Cancers
|August 29, 2024
概括
在接受机器人辅助激进囊切除术 (RARC) 的肌肉侵入性膀癌 (MIBC) 患者的手术前水与较差的生存结果有关. 这一发现表明,水缩会影响超越瘤阶段的预后,并且在患者选择中需要考虑.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 手术瘤学手术瘤学
- 在瘤学瘤学.
背景情况:
- 机器人辅助激进囊切除术 (RARC) 越来越多地用于肌肉侵入性膀癌 (MIBC).
- 预测RARC结果的预测者需要进一步调查.
- 在接受RARC的MIBC患者中,手术前水性的预后意义尚未得到充分确立.
研究的目的:
- 为了研究手术前水缩对RARC治疗的MIBC患者的瘤结局的影响.
- 为了确定水解作为MIBC管理中的潜在预后因素.
主要方法:
- 来自亚洲RARC联盟的数据分析,这是一个多中心注册表.
- 536名非转移性MIBC患者的分类,分为水化 (n=107) 和没有水化 (n=429) 组.
- 对生存结果的多变量回归分析,包括10年无病生存率 (DFS) 和整体生存率 (OS).
主要成果:
- 在分析的MIBC患者中,有20%的患者出现了水性.
- 手术前的水解是较低DFS (HR=1.701) 和OS (HR=1.834) 的显著预测因素.
- 亚组分析在T2或以上和T3或以上MIBC阶段证实了这些不良影响.
结论:
- 手术前的水解对于接受RARC的MIBC患者具有独立的预后影响,超出了已建立的瘤分期.
- 在为RARC选择MIBC患者时,应考虑水解的存在.
- 对这种关联背后的机制进行进一步的研究是有必要的.
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