超声指导肺活检的分子诊断产量和安全概况:一个横截面研究
Vito D'Agnano1,2, Fabio Perrotta1,2, Giulia Maria Stella3
1Department of Translational Medical Sciences, University of Campania L. Vanvitelli, 80131 Naples, Italy.
Cancers
|August 29, 2024
概括
超声导向肺活检对于诊断肺癌和进行分子分析是安全有效的. 这种最少的侵入性方法提供了高的诊断准确性,适合PD-L1测试和识别肺淋巴瘤.
科学领域:
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 肺癌的精确瘤学需要准确的组织诊断和分子分析.
- 目前的方法包括CT导向活检和支气管镜检查.
- 超声导向活检显示出作为一种安全有效的替代方案的希望.
研究的目的:
- 评估超声导向皮肤肺损伤活检 (US-PLLB) 的安全性和诊断产量.
- 评估该程序对综合癌症分子分析和PD-L1测试的有效性.
主要方法:
- 对100名连续接受US-PLLB的患者进行了回顾性分析,因为怀疑患有肺癌.
- 使用下一代测序 (Genexus) 或PCR进行分子分析.
- 通过免疫组织化学评估的编程死亡配体1 (PD-L1) 表达.
主要成果:
- 在95名可评估患者中,US-PLLB在93名患者中实现了96.84%的诊断准确率.
- 在大多数NSCLC病例中,特别是腺癌中,完整的分子分析和PD-L1测试都取得了成功.
- 整体并发症率较低 (9.47%),主要不良事件是肺胸炎和轻度血栓塞.
结论:
- 超声导向肺活检是疑似肺恶性瘤的安全和最小侵入性手术.
- 它为分子分析和PD-L1测试提供了出色的诊断产量.
- 美国PLLB也可能有效诊断肺淋巴瘤.
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