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在实验室中测试第二代原型配件,用于单个跨的左心室辅助装置植入

Florian Meissner¹, Michelle Costa Galbas¹, Hendrik Straky¹

¹Department of Cardiovascular Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany.

Bioengineering (Basel, Switzerland)

|August 29, 2024

概括

一种新的双光门配件使左心室辅助装置 (LVAD) 能够在没有大动脉解剖的情况下植入. 这项研究证实了其在临床前模型中的可行性,安全性和血液动力学有效性.

科学领域:

心血管外科心血管外科
生物医学工程生物医学工程
医疗器械医疗器械

背景情况:

传统的左心室辅助装置 (LVAD) 植入需要对上升性大动脉进行解剖,这是一个复杂的手术步骤.
开发了一种新的双光门配件,以简化LVAD植入,消除对大动脉解剖的需要.

研究的目的:

评估新型LVAD配件的可行性,解剖学适合性,手术安全性和血液动力学有效性.
为了证明配件在没有直接大动脉连接的情况下促进LVAD植入的潜力.

主要方法:

该配件植入了十只母猪在心肺旁路术中.
使用气球导管的专业技术被用来引导辅助器的输出通道穿过大动脉.
植入后的评估包括心声回声和弹道测试的性能.

主要成果:

在十分之九的动物中,成功实现了植入,并确认了正确的配件放置.
心声图显示在植入后没有显著的大动脉反.
在上坡测试期间,LVAD流量显著增加,表明血液动力学功能保持 (3.7 ± 1.2 到 5.4 ± 1.2 L/分钟).
尸体解剖显示没有门病变或器件血栓形成.

结论:

开发的配件可以实现左心室辅助装置的植入,而不会影响的性能或需要大动脉解剖.
这种新的方法显示出对简化LVAD程序的希望,并保证进一步的研究,包括长期研究和优化离植入.

关键词:

动物试验动物试验.心脏衰竭是因为心脏衰竭.在活体中,活体中左心室辅助装置的使用医疗器械开发医疗器械开发猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪通过腹腔外流输出移植.

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