奎尔素补充改善肠道消化和吸收功能和小鼠的微生物群 养蛋白质氧化大豆饭:转录和微生物学的见解
Zhiyong Wang1, Peng Wang1, Yanmin Zhou1
1College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing 210095, China.
Animals : an open access journal from MDPI
|August 29, 2024
概括
奎尔素补充剂减轻了氧化大豆粉对老鼠消化和营养吸收的负面影响. 它通过调节有益细菌和增强消化酶活性来改善肠道健康.
科学领域:
- 动物营养 动物营养
- 营养生物化学 营养生物化学
- 肠道微生物组研究研究
背景情况:
- 蛋白质氧化大豆粉会损害老鼠的消化和吸收功能.
- 奎尔是一种具有潜在健康益处的黄类化合物,但其在减轻饮食挑战方面的作用尚未完全理解.
研究的目的:
- 研究昆素减轻蛋白质氧化大豆粉对大鼠消化和吸收功能的不良影响的营养机制.
- 分析氨酸对肠道微生物群和与营养代谢相关的基因表达的影响.
主要方法:
- 一项2x2因子设计研究,涉及48只雄性斯普拉格-道利大鼠,在28天内食新鲜或蛋白质氧化大豆粉,或不补充氨酸 (400 mg/kg).
- 评价器官重量,肠道形态,酶活动,营养消化能力,转录组学和肠道微生物组学.
主要成果:
- 蛋白质氧化大豆粉减少了器官重量,十二指肠高度,脂酶活性和营养消化能力,同时改变了肠道微生物群的组成.
- 奎思补充剂可以逆转这些负面影响,改善肠道形态,酶活性,营养吸收,促进有益的肠道细菌.
- 转录基因分析表明,奎尔提升了脂质消化和吸收途径和基本氨基酸运输的调节.
结论:
- 奎尔素有效地减轻了蛋白质氧化大豆粉对大鼠消化和吸收功能的有害影响.
- 奎尔的益处与改善肠道形态,增强消化酶活性,更好地吸收营养素和肠道微生物组的有利调节有关.
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