萨尔蒙氏菌EntericA变种的有限出现 赛洛瓦婴儿菌变种与减少的菌体敏感性在PhagoVet-treated Broilers中
Sandra Sevilla-Navarro1, Jennifer Otero2, Júlia López-Pérez2
1Centro de Calidad Avícola y Alimentación Animal de la Comunidad Valenciana (CECAV), 12539 Alquerias NP, Castellón, Spain.
Animals : an open access journal from MDPI
|August 29, 2024
概括
使用PhagoVet的菌体治疗有效控制了 brojlers中的沙门氏菌. 虽然在一项试验中出现了降低菌素敏感性变体 (RPSV),但它们不太可能影响整体治疗疗效.
科学领域:
- 兽医微生物学 兽医微生物学
- 细菌治疗疗法是一种细菌治疗.
- 禽畜科学 禽畜科学 禽畜科学
背景情况:
- 沙门氏菌 (Salmonella enterica serovar Infantis,S. Infantis) 是家禽行业的一个重要病原体.
- 菌体治疗为控制S. Infantis提供了抗生素的有希望的替代方案.
- 降低菌敏感性变体 (RPSV) 的出现可能会影响菌治疗的有效性.
研究的目的:
- 为了调查S. Infantis RPSV在用PhagoVet.治疗的肉中出现的情况.
- 为了描述PhagoVet产品中的菌体.
- 为了评估PhagoVet对肉S. Infantis的疗效.
主要方法:
- 用传输电子显微镜,基因组测序和感染分析来描述PhagoVet中的细菌体.
- 进行了两项肉试验,使用不同的S. Infantis挑战剂量和PhagoVet给药水平.
- 在整个试验中,监测了便和Ceca中的细菌数量和RPSV存在.
主要成果:
- 这四种PhagoVet菌体属于不同的属,对18种沙门氏菌血清型表现出广泛的活性.
- 在试验1中,PhagoVet显著降低了肉便中的S. Infantis数量,没有检测到RPSV.
- 在第二个试验中,在便和中检测到了RPSV,但PhagoVet仍然证明了对S. Infantis的有效性.
结论:
- PhagoVet有效控制肉中S. Infantis感染的情况.
- RPSV的出现是一个考虑因素,但不太可能显著地影响PhagoVet的整体疗效.
- 菌体治疗为管理家禽生产中的沙门氏菌提供了一种可行的策略.
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