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针对 Staphylococcus aureus 中的 N- 乙糖氨基酶,使用 胺基糖抑制剂

Janja Sluga1,2, Tihomir Tomašič2, Marko Anderluh2

  • 1Laboratory for Cheminformatics, Theory Department, National Institute of Chemistry, Hajdrihova ulica 19, 1000 Ljubljana, Slovenia.

Antibiotics (Basel, Switzerland)
|August 29, 2024
PubMed
概括

新的伊米诺糖衍生物在抑制自解素E (AtlE) 方面表现有前途,该酶是多药耐药黄金葡萄球菌中的关键酶. 这项研究提供了潜在的新策略来打击日益增长的细菌抗生素耐药性.

关键词:
奥托利辛E的使用方法酶抑制抑制酶的抑制.葡萄糖酸酸酶是什么 葡萄糖酸酸酶是什么不同的糖类不同的糖类表面的等离子体共振.

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Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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