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使用机器学习在危重病患者中对脂质体安二B对功能影响的真实世界数据观察分析

Ignasi Sacanella¹, Erika Esteve-Pitarch¹, Jessica Guevara-Chaux^2,3

¹Department of Pharmacy, Hospital Universitari Joan XXIII, 43005 Tarragona, Spain.

Antibiotics (Basel, Switzerland)

|August 29, 2024

概括

在重症患者中使用脂质体安福特 B (L-AmB) 并没有显示急性损伤 (AKI) 的增加. L-AmB似乎是安全的,AKI的发展是多因素的.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
关键护理医学关键护理医学
传染性疾病传染性疾病

背景情况:

脂质体安二乙 (L-AmB) 是对严重的侵入性真菌感染的主要治疗方法.
对L-AmB的潜在毒性需要仔细监测.

研究的目的:

在接受L-AmB超过48小时的重症患者中评估急性损伤 (AKI) 的发生率.
确定在这个患者队列中促进AKI发展的因素.

主要方法:

回顾性,观察性,单中心研究设计.
从电子医疗记录中提取的数据,包括临床,人口和实验室变量.
在总人口中分析了AKI发病率,并根据基线肌素风险 (低/高) 分层.
采用随机森林模型来确定与AKI相关的因素.

主要成果:

包括67名重症患者 (平均年龄61岁,67%男性,中位数SOFA4).
整体的AKI发病率为26.8% (低风险:25%,高风险:13%).
没有观察到有意义的血清肌素变化,高风险亚组的血清肌素减少.
诺拉上腺素,SOFA评分,化物,,C反应蛋白,和公素被确定为AKI贡献者.

结论:

在接受L-AmB的患者中,急性损伤的发展是多因素的.
在关键病情患者中,L-AmB的使用似乎是安全的,因为它对脏有毒性.

关键词:

急性脏损伤急性脏损伤是什么抗真菌剂是一种抗真菌剂.关键护理关键护理的关键护理脂质体安波特里辛B的使用情况机器学习是机器学习.随机的森林随机的森林

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