对于周围假肢关节感染,在第一次和随后的两阶段修订之间,有没有生物体的形状和抵抗模式发生变化?
Helmut Ahrens1, Amelie Constanze Steinicke1, Georg Gosheger1
1Department of Orthopedics and Tumor Orthopedics, Muenster University Hospital, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany.
Antibiotics (Basel, Switzerland)
|August 29, 2024
概括
对周围假肢关节感染 (PJI) 进行重复的两阶段检查会增加多微生物和耐药感染的风险. 虽然格拉姆阴性生物体会影响生存率,但耐药微生物并没有显著影响这项研究的结果.
科学领域:
- 整形外科手术 整形外科手术
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 周围假肢关节感染 (PJI) 治疗受到抗生素耐药性增加的挑战.
- 对复发性PJI进行重复的两阶段修复手术具有重感染的高风险.
- 在重复手术后复发性PJI中微生物配置的作用尚不清楚.
研究的目的:
- 分析患者的微生物概况,这些患者在复发性PJI中经历了重复的两阶段修订.
- 调查微生物频谱和耐药性的对无再感染生存的影响.
主要方法:
- 对46名接受PJI (2011-2017) 重复两阶段修订的患者进行了回顾性,单中心分析.
- 分析了微生物学发现,包括频谱和耐药性测试.
- 评估了没有再感染的存活率.
主要成果:
- 凝固酶阴性葡萄球菌 (39%) 和阴性生物 (28%) 是最常见的病原体.
- 显著增加的多微生物,难以治疗的耐药性和格拉姆阴性感染.
- 耐甲西林的葡萄球菌和口服抗生素耐药性是普遍存在的.
- 格拉姆阴性感染与减少无感染生存率有关;耐药生物体没有.
结论:
- 对PJI进行重复的两阶段修订与多微生物和耐药生物体的更高患病率有关.
- 这些耐药生物体对生存率的临床影响需要进一步研究.
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