在超重/肥胖人口中研究表观遗传年龄和心血管风险之间的关系
Davide Marinello1, Chiara Favero1, Benedetta Albetti1
1EPIGET LAB, Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2024-2027, University of Milan, 20122 Milan, Italy.
Biomedicines
|August 29, 2024
概括
心血管风险因素加快了超重或肥胖个体的表观遗传年龄 (DNAm年龄). 这种表观遗传年龄加速与更高的心血管风险有关,这表明DNAm年龄是潜在的生物标志物.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 心血管健康 心血管健康
- 生物标志物 生物标志物
背景情况:
- 心血管疾病是全球死亡的主要原因,由肥胖,高血压和糖尿病等可修改的风险因素驱动.
- 表观遗传年龄 (DNAm年龄) 反映了生理健康,并可能受到心血管风险因素的影响.
- 弗雷明汉风险评分 (FRS) 是衡量心血管风险的标准指标.
研究的目的:
- 调查心血管风险因素与DNAm衰老加速之间的关系.
- 使用FRS评估DNAm年龄加速和心血管风险之间的关联.
主要方法:
- 研究人口:190名超重/肥胖个体.
- 使用Zbieć-Piekarska等计算的DNAm年龄. 这是对外围白细胞DNA的估计器.
- 线性回归模型用于分析风险因素,DNAm年龄加速和FRS之间的关联.
主要成果:
- DNAm年龄加速与静脉血压,心率,血糖和糖化血红蛋白的增加显著相关.
- 糖尿病,更年期状态,中性粒细胞和颗粒细胞数量升高也与加速DNAm年龄有关.
- 发现DNAm年龄加速将Framingham风险得分提高了5.3%.
结论:
- 心血管风险因素加速DNAm在超重/肥胖个体的年龄.
- DNAm年龄加速可能成为累积心血管风险的新生物标志物.
- 这项研究提供了第一个证据,将心血管风险因素与该人口中加速DNAm年龄联系起来.
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