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聚糖可减轻环胺诱导的男性生殖损伤,通过减少氧化应激和亡
Hang Zhang1, Nannan Li1, Yukun Zhang2
1State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Biomedicines
|August 29, 2024
概括
甘光多糖 (GLPP) 保护男性生育能力免受化疗损伤. 在小鼠中,GLPP降低了氧化应激和亡,保持了精子生产和丸健康.
科学领域:
- 生殖生物学 生殖生物学
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
背景情况:
- 化疗是男性不孕症的一个重要原因.
- 在化疗期间保护男性生殖健康需要有效的干预措施.
- 甘光多糖 (GLPP) 具有多种不同的药理特性.
研究的目的:
- 评估GLPP对化疗引起的男性生殖器损伤的保护作用.
- 在小鼠模型中研究GLPP在保护精子生产和丸功能方面的有效性.
主要方法:
- 雄性ICR小鼠接受了循环胺 (CP) 治疗,以诱导丸损伤.
- 小鼠接受了不同剂量的GLPP与CP的同时.
- 评估生殖器官系数,精子参数,性激素水平,丸组织学,氧化应激标志物和与亡相关的蛋白质.
主要成果:
- 剂量依赖的GLPP缓解了CP诱导的生殖器官系数和精子参数的减少.
- GLPP改善了丸组织学,性激素水平和精子质量.
- 通过调节SOD,GSH,CAT,Nrf2,HO-1,MDA和Keap-1水平,GLPP降低了氧化应激,并通过改变Bax和Bcl-2表达来抑制亡.
结论:
- 在小鼠中,GLPP显示出显著的保护作用,防止化疗诱导的精子发生损伤.
- 通过减少丸组织中的氧化应激和亡,GLPP可减轻损伤.
- 在接受化疗的男性患者中,GLPP具有作为治疗剂的潜力.
关键词:
这是GLPP GLPP GLPP.灭症 (apoptosis) 是一种死亡的过程.化疗 化疗是一种化学疗法.不孕症 不孕不育 不孕不育 不孕不育氧化应激是一种氧化应激.精子生成性阶段 精子生成性阶段更多相关视频
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