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心血管疾病中的性别差异:探索微生物群和免疫力的作用
Laura Franza1,2, Mario Caldarelli3,4, Emanuele Rocco Villani5,6
1Emergency, Anesthesiological and Reanimation Sciences Department, Fondazione Policlinico Universitario A. Gemelli-IRCCS of Rome, 00168 Rome, Italy.
Biomedicines
|August 29, 2024
概括
心血管疾病 (CVD) 呈现出性别特异性的模式,可能由肠道微生物群 (GM) 差异介导. 这篇评论探讨了性别,转基因和心血管疾病之间的相互作用,以获得治疗见解.
科学领域:
- 心脏病学 心脏病学
- 微生物学 微生物学
- 内分泌学 在内分泌学.
背景情况:
- 心血管疾病 (CVD) 是全球主要的死亡原因,男性和女性的患病率和表现不同.
- 性激素和肠道微生物群 (GM) 涉及到心血管疾病,基因组合因性别而异.
- 来自肠道的代谢物与心血管疾病和脏疾病有关,可能会影响心血管疾病的进展.
研究的目的:
- 综合审查性,肠道微生物群和心血管疾病之间的复杂相互作用.
- 讨论由肠道微生物群影响的心血管疾病中性别差异的潜在机制.
- 探索针对肠道微生物群进行心血管疾病管理的新兴治疗策略.
主要方法:
- 这项研究是一种叙事性审查.
- 文献搜索的重点是性别,肠道微生物群和心血管疾病之间的关系.
- 对性激素,肠道微生物群组成及其对心血管疾病的影响现有研究的分析.
主要成果:
- 有证据表明,男性和女性之间的肠道微生物群组成存在显著差异.
- 肠道微生物群及其代谢物可能在心血管疾病中观察到的性别差异中起到调解作用.
- 性激素影响肠道微生物群,导致心血管健康的性别差异.
结论:
- 肠道微生物群在心血管健康中起着至关重要的作用,并且可能在心血管疾病中调解性别差异.
- 了解性肠道微生物群-心血管疾病轴对于开发有针对性的治疗干预至关重要.
- 未来的研究应该专注于肠道微生物群的性别特异调制,以预防和治疗心血管疾病.
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