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血骨形态遗传蛋白6水平降低在败血症和败血症休克患者中
Niklas Schmidtner1, Alexander Utrata1, Patricia Mester1
1Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious Diseases, University Hospital Regensburg, 93053 Regensburg, Germany.
骨形态遗传蛋白6 (BMP6) 水平在全身炎症反应综合征 (SIRS) 中正常,但在败血症和败血性休克中降低. 这表明BMP6在这些条件下不会导致铁失调.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 关键护理医学 关键护理医学
背景情况:
- 传染病通常会导致铁含量降低和肝素增加,肝素是铁出口的关键调节剂.
- 骨形态遗传蛋白6 (BMP6) 影响肝素的表达,但其在败血症中的作用尚不清楚.
研究的目的:
- 在患有全身炎症反应综合征 (SIRS),败血症和败血性休克的患者中检查血BMP6水平.
- 确定BMP6与炎症标志物和临床结果的相关性.
主要方法:
- 在38名SIRS,39名败血症和78名败血性休克患者的血BMP6水平被测量.
- 患者组之间的BMP6水平进行了比较,并与前素,C反应蛋白和临床数据相关联.
主要成果:
- 血BMP6水平在败血症和败血性休克中相似,低于SIRS和健康对照.
- BMP6水平与炎症标志物 (前素,CRP) 或临床因素 (如通风或血管压缩剂使用) 不相关.
- 在幸存者和非幸存者之间没有观察到BMP6的差异,也没有观察到与细菌,SARS-CoV-2或铁参数有关的差异.
结论:
- SIRS患者的血BMP6水平正常,而败血症和败血休克患者的水平降低.
- 在SIRS,败血症和败血症休克期间观察到的肝素的增加和铁的减少并不是由BMP6升高驱动的.
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