探索与原发性开放角玻璃眼和脱皮玻璃眼相关的认知障碍
Yoichi Kadoh1, Suguru Kubota1, Soichiro Shimomine1
1Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan.
Biomedicines
|August 29, 2024
概括
与初级开角玻璃眼 (PG) 患者相比,脱皮玻璃眼 (EG) 患者表现出较差的认知功能和更高的先进糖化最终产品 (AGEs). AGEs的积累与EG的认知衰退有关,这表明非侵入性监测的潜力.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 玻璃眼,不可逆转的失明的主要原因,越来越多地认识到其潜在的系统性关联.
- 认知障碍在老年人群中越来越令人担忧,其与眼部疾病的联系需要进一步调查.
研究的目的:
- 为了研究不同青光眼亚型与日本患者的认知功能之间的关系.
- 探索高级糖化最终产品 (AGEs) 和其他因素在青光眼患者认知衰退中的作用.
主要方法:
- 一项涉及620名日本患者的队列研究,分为初级开角青光眼 (PG),脱皮青光眼 (EG) 和非青光眼的对照组.
- 使用Mini-Cog测试评估认知功能;通过指尖测量高级糖化最终产品 (AGEs).
- 统计分析,包括多变量分析和考虑诸如年龄和眼内压力 (IOP) 等混因素.
主要成果:
- 与初级开角眼 (PG) 患者相比,剥皮眼 (EG) 患者的Mini-Cog得分 (表明认知功能较差) 显著较低 (p < 0.0001).
- 在EG组,指尖AGE水平明显高于PG组 (p = 0.0014).
- 高AGE水平与EG组的认知衰退和降低平均视野相关,年龄是混因素. 在AGE和皮肤胡卜素水平之间发现了反向相关性.
结论:
- 与初级开角绿内障相比,脱皮绿内障与认知功能的更大下降有关.
- 先进的糖化最终产品 (AGEs) 的积累可能在EG患者的认知障碍和视野损失中起作用.
- 对AGE和皮肤胡卜素的非侵入性指尖测量显示,它有望监测青光眼患者的眼睛和认知健康.
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