基于口腔癌风险习惯的唾液样本分析:一个观察性横截面研究
Rahmi Amtha1, Indrayadi Gunardi1, Armelia Sari Widyarman2
1Oral Medicine Department, Faculty of Dentistry, Universitas Trisakti, Jakarta 11440, Indonesia.
Biomedicines
|August 29, 2024
概括
口腔癌的危险因素,如吸烟和酒精改变唾液. 具有这些习惯的个体表现出明显更高的唾液介质蛋白-1β (IL-1β) 水平,表明了明显的唾液形状.
科学领域:
- 口腔健康研究 口腔健康研究
- 发现生物标志物的发现.
- 癌症流行病学癌症流行病学
背景情况:
- 印度尼西亚的文化习惯,包括白菜,吸烟和饮酒,是口腔癌的风险因素.
- 这些习惯可能会影响唾液状况,这对于保持口腔健康至关重要.
研究的目的:
- 调查和比较具有和没有口腔癌风险因素的个体的唾液状况.
- 为了确定与口腔癌风险相关的潜在的唾液生物标志物.
主要方法:
- 来自49名具有口腔癌风险因素的个体的非刺激唾液样本的分析.
- 唾液参数的测量:pH,流量 (FR),粘度,颜色,度,以及互白素-1β (IL-1β) 和IL-8的水平.
- 使用Chi-square和t测试进行统计分析来比较群体.
主要成果:
- 在具有口腔癌风险因素的人群中观察到显著增加的唾液IL-1β水平 (p = 0.009).
- 吸烟 (p = 0.021; OR = 2.94) 和饮酒 (p = 0.007; OR = 4.96) 与增加IL-1β相关.
- 两组之间没有发现唾液粘度,颜色,度,流速,酸度或IL-8水平的显著差异 (p > 0.05).
结论:
- 患有口腔癌风险因素的个体表现出明显的唾液IL-1β配置文件.
- 特别是酒精消费与唾液IL-1β水平的变化密切相关,这表明它具有作为生物标志物的潜力.
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