环境因素对自身免疫性甲状腺炎发展的影响 - 综述
Wojciech Cyna1, Aleksandra Wojciechowska1, Weronika Szybiak-Skora1
1Student's Scientific Society, Endocrinology Section at the Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Biomedicines
|August 29, 2024
概括
环境因素,如饮食,感染和生活方式的选择显著影响自身免疫性甲状腺炎的风险. 了解这些触发因素可以帮助减少疾病的发生和严重程度.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 环境健康 环境健康
背景情况:
- 自身免疫性甲状腺炎 (橋本甲状腺炎) 是最常见的自身免疫性疾病.
- 虽然遗传因素起着作用,但对自身免疫性甲状腺炎病原体的环境影响越来越被认可.
- 这种情况通常呈现为甲状腺功能低下症,但也可以表现为甲状腺功能低下症或甲状腺功能过高症.
研究的目的:
- 审查和分析各种环境因素与自身免疫性甲状腺炎的发展之间的关联.
- 巩固当前关于海西莫托甲状腺炎环境风险因素的知识.
主要方法:
- 对环境因素和自身免疫性甲状腺炎的现有文献进行系统审查.
- 对将特定环境暴露与疾病风险联系起来的数据进行分析.
主要成果:
- 确定的主要环境因素包括缺少和维生素D/.
- 病毒性 (埃普斯坦-巴尔病毒,帕尔沃病毒B19,疹病毒6A,SARS-CoV-2) 和细菌性 (Helicobacter pylori) 感染都在其中.
- 其他因素包括微生物组的破坏,某些药物 (干扰素α,氨酸激酶抑制剂),压力,气候和吸烟.
结论:
- 环境因素显著影响自身免疫性甲状腺炎的风险和潜在的过程.
- 根据已识别的风险因素,可修改的生活方式和饮食改变可能有助于减轻疾病的发展和进展.
- 对环境影响的确切机制进行进一步的研究是有必要的.
相关概念视频
Autoimmune Disorders
2.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
2.4K
Hyperthyroidism II: Pathophysiology
28
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH...
28
Graves' Disease I: Introduction
23
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence...
23
Graves Disease II: Pathophysiology
26
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor,...
26
Hypothyroidism II: Pathophysiology
26
Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
26
Type I Diabetes I: Introduction
45
Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1...
45


