肠道微生物群,免疫力障碍和肝细胞癌
Emidio Scarpellini1, Giuseppe Guido Maria Scarlata2, Valeria Santori3
1Translational Research Center in Gastro-Intestinal Disorders (T.A.R.G.I.D.), Gasthuisberg University Hospital, KU Leuven, Herestraat 49, 3000 Lueven, Belgium.
Biomedicines
|August 29, 2024
概括
肠道微生物群失生症影响肝癌的进展和治疗. 修改肠道细菌可能会改善接受免疫治疗的肝细胞癌患者的结果.
科学领域:
- 肝细胞癌 (HCC) 病原发生
- 胃肠道瘤学 胃肠道瘤学
- 免疫治疗生物标志物 免疫治疗生物标志物
背景情况:
- 肝细胞癌 (HCC) 呈现出高死亡率,与免疫失调和改变胆酸代谢有关.
- 肠道微生物群 (GM) 显著影响HCC的发展和对免疫检查点抑制剂 (ICI) 等治疗的反应.
- 目前ICI对HCC疗效的局限性源于缺乏预测生物标志物.
研究的目的:
- 审查关于HCC治疗的文献,强调免疫系统,胆酸代谢和肠道微生物群失调的作用.
- 确定潜在的生物标志物来预测肝癌患者对免疫检查点抑制剂的反应.
主要方法:
- 在PubMed,Medline以及主要的胃肠病学/肝病学会议记录中进行文献搜索.
- 关键词包括:肠道微生物群,免疫系统,肝癌和检查点抑制剂.
主要成果:
- 肠道微生物群失生症与HCC中免疫反应和胆酸代谢的改变密切相关.
- 肠道微生物群的组成显示出作为预测肝癌ICI反应的生物标志物的潜力.
- 针对肠道微生物群的干预措施可能会提高ICI治疗HCC的疗效.
结论:
- 肠道微生物群失调是肝癌发病的一个关键因素,影响治疗结果.
- 调节肠道微生物群为改善HCC预后和免疫治疗反应提供了一个有希望的策略.
- 需要进一步的研究来确定转基因调节在HCC中的直接治疗益处.
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